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KMID : 1141020100100020017
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Journal of Applied Oriental Medicine
2010 Volume.10 No. 2 p.17 ~ p.23
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Antioxidant Activities of Xanthium strumarium Fruit and Stem Extracts
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Min Young-Sil
Park Jae-Ho
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Abstract
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Objective: This study was conducted to investigate the antioxidant activities of Xanthium strumarium fruit and stem extracts.
Methods: Antioxidant activities of Xanthium strumarium fruit and stem extracted with various concentrations of ethylacetate (EtOAC) were investigated. The 1,1- diphenyl-2-picrylhydrazyl (DPPH) radical and hydroxyl scavenging assay and Fe2+ chelating assay were performed for antioxidative effect and φX-174 RF I DNA cleavage assay and intracellular DNA damage assay were used for inhibitory effect of intracellular DNA damage.
Results: When the different concentrations of EtOAC (0.32, 1.6, 8, 40, 200㎍/㎖) were tested in fruit extraction of Xanthium strumarium, the extracts at 200 ug/ml resulted in the highest DPPH radical and hydroxyl scavenging and Fe2+ chelating activities, which were 86.05, 59.52, and 48.21%, respectively. Fruit extracts showed the higher antioxidative activities and inhibitory effects than stem extracts at same concentration.
Conclusion: The present study indicated that fruit extracts of Xanthium strumarium showed the higher antioxidant activities and protective effect of DNA damage against the oxidative stress compared with the stem extracts.
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KEYWORD
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Xanthium strumarium, antioxidant activity, Fe2+ chelating, DNA damage
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